Recombinant Human BH3 Interacting Domain Death Agonist,GST-tagged

• Cat.No.: BID-1437H
• Product Overview: Recombinant full-length human BID was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 52kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: BID is a BH3 interacting death domain that heterodimerizes with either agonist BAX or antagonist BCL2. BID is a member of the BCL-2 family of cell death regulators and is a mediator of mitochondrial damage induced by caspase-8 (CASP8). BID initiates apoptosis by binding to regulatory sites on prosurvival BCL2 proteins to directly neutralize their function. Multiple alternatively spliced transcript variants of BID have been found, but the full-length nature of some variants has not been defined. BID together with Cathepsins play an important role in the actions of Camptothecin on breast cancer cells.
• Sequence: Full-length.
• Applications: Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: BID BH3 interacting domain death agonist [ Homo sapiens ]
• Synonyms: BID; BH3 interacting domain death agonist; FP497; MGC15319; MGC42355; p22 BID
• Gene ID: 637
• mRNA Refseq: NM_00119
• Protein Refseq: NP_001187
• MIM: 601997
• UniProt ID: P55957
• Chromosome Location: 22q11.2
• Pathway: Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS); Apoptosis; Natural killer cell mediated cytotoxicity; Pathways in cancer; p53 signaling pathway; Apoptosis
• Function: death receptor binding; protein binding