Recombinant Human BCL2L1 protein, GST-tagged

• Cat.No.: BCL2L1-323H
• Product Overview: Recombinant Human BCL2L1 protein (Met1-Arg212), fused to GST tag at N-terminus, was expressed in E.coli.

Specification

• Description: Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1/Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1/Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
• Source: E.coli
• Species: Human
• Tag: GST
• Form: Lyophilized from 0.22 um filtered solution in 20 mM Tris, 100 mM NaCl, pH7.5 with 10 mM GSH, 10% trehalose.
• Molecular Mass: The protein has a calculated MW of 50.5 kDa. The protein migrates as 46 kDa under reducing (R) condition (SDS-PAGE).
• Protein length: 212
• Endotoxin: Less than 1.0 EU per ug by the LAL method.
• Purity: >92% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20 centigrade to -70 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: BCL2L1
• Official Symbol: BCL2L1
• Synonyms: BCL2L1; BCL2-like 1; bcl-2-like protein 1; Bcl X; bcl xL; bcl xS; BCL2L; BCLX; PPP1R52; protein phosphatase 1; regulatory subunit 52; apoptosis regulator Bcl-X; protein phosphatase 1, regulatory subunit 52; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; BCL-XL/S; DKFZp781P2092
• Gene ID: 598
• mRNA Refseq: NM_001191
• Protein Refseq: NP_001182
• MIM: 600039
• UniProt ID: Q07817