Recombinant Human BBS4, GST-tagged

• Cat.No.: BBS4-10155H
• Product Overview: Recombinant Human BBS4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: N-term-351a.a.
• Description: This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse. The similar phenotypes exhibited by mutations in BBS gene family members are likely due to the proteins shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene has sequence similarity to O-linked N-acetylglucosamine (O-GlcNAc) transferases in plants and archaebacteria and in human forms a multi-protein "BBSome" complex with six other BBS proteins. Alternative splice variants have been described but their predicted protein products have not been experimentally verified.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: BBS4 Bardet-Biedl syndrome 4 [ Homo sapiens ]
• Official Symbol: BBS4
• Synonyms: BBS4; Bardet-Biedl syndrome 4; Bardet-Biedl syndrome 4 protein
• Gene ID: 585
• mRNA Refseq: NM_001252678
• Protein Refseq: NP_001239607
• MIM: 600374
• UniProt ID: Q96RK4
• Chromosome Location: 15q22.3-q23
• Function: alpha-tubulin binding; beta-tubulin binding; dynactin binding; microtubule motor activity; protein binding