Recombinant Human BAIAP2, His-tagged

• Cat.No.: BAIAP2-27437TH
• Product Overview: Recombinant full length Human BAIAP2 with C terminal His tag; 530 aa, 58.4kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 522 amino acids
• Description: The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
• Conjugation: HIS
• Molecular Weight: 58.400kDa inclusive of tags
• Tissue specificity: Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:30% Glycerol, 0.32% Tris HCl, 0.02% DTT, 0.58% Sodium chloride
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MSLSRSEEMH RLTENVYKTI MEQFNPSLRN FIAMGKNYEK ALAGVTYAAK GYFDALVKMG ELASESQGSK ELGDVLFQMA EVHRQIQNQL EEMLKSFHNE LLTQLEQKVE LDSRYLSAAL KKYQTEQRSK GDALDKCQAE LKKLRKKSQG SKNPQKYSDK ELQYIDAISN KQGELENYVSDGYKTALTEE RRRFCFLVEK QCAVAKNSAA YHSKGKELLA QKLPLWQQAC ADPSKIPERA VQLMQQVASN GATLPSALSA SKSNLVISDP IPGAKPLPVP PELAPFVGRM SAQESTPIMN GVTGPDGEDY SPWADRKAAQ PKSLSPPQSQ SKLSDSYSNT LPVRKSVTPK NSYATTAENKTLPRSSSMAA GLERNGRMRV KAIFSHAAGD NSTLLSFKEG DLITLLVPEA RDGWHYGESE KTKMRGWFPF SYTRVLDSDG SDRLHMSLQQ GKSSSTGNLL DKDDLAIPPP DYGAASRAFP AQTASGFKQR PYSVAVPAFS QGLDDYGARS MSSGSGTLVS TVVEHHHHHH
• Sequence Similarities: Contains 1 IMD (IRSp53/MIM homology) domain.Contains 1 SH3 domain.

Gene Information

• Gene Name: BAIAP2 BAI1-associated protein 2 [ Homo sapiens ]
• Official Symbol: BAIAP2
• Synonyms: BAIAP2; BAI1-associated protein 2; brain-specific angiogenesis inhibitor 1-associated protein 2; BAP2
• Gene ID: 10458
• mRNA Refseq: NM_001144888
• Protein Refseq: NP_001138360
• MIM: 605475
• Uniprot ID: Q9UQB8
• Chromosome Location: 17q25
• Pathway: Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; CDC42 signaling events, organism-specific biosystem; ErbB1 downstream signaling, organism-specific biosystem; RAC1 signaling pathway, organism-specific biosystem
• Function: SH3 domain binding; cytoskeletal adaptor activity; proline-rich region binding; protein C-terminus binding; protein binding