Recombinant Human BAI1-Associated Protein 2, His-tagged

• Cat.No.: BAIAP2-1373H
• Product Overview: Recombinanthuman BAIAP2protein, fused to His-tag at C-terminus, was expressed in E.coli andpurified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: BAIAP2 is aubiquitous regulator of the actin cytoskeleton. It mediates filopodiaformation under the control of Rho-family GTPases. BAIAP2 is expressed in thecytoplasm and links small membrane-bound G-proteins to cytoplasmic effectorproteins. This protein functions as an insulin receptor tyrosine kinasesubstrate and suggests a role for insulin in the central nervous system.
• Form: Liquid. In 20 mMTris-HCl buffer (pH 8.0) containing 1 mM DTT, 30% glycerol, 0.1M NaCl.
• Molecular Weight: 58.4 kDa(530 aa)
• Purity: > 90%by SDS-PAGE
• Concentration: 0.5mg/ml(determined by Bradford assay)
• Sequences of aminoacids: MSLSRSEEMHRLTENVYKTI MEQFNPSLRN FIAMGKNYEK ALAGVTYAAK GYFDALVKMG ELASESQGSK ELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVE LDSRYLSAAL KKYQTEQRSK GDALDKCQAE LKKLRKKSQG SKNPQKYSDK ELQYIDAISNKQGELENYVS DGYKTALTEE RRRFCFLVEK QCAVAKNSAA YHSKGKELLA QKLPLWQQAC ADPSKIPERAVQLMQQVASN GATLPSALSA SKSNLVISDP IPGAKPLPVPPELAPFVGRM SAQESTPIMN GVTGPDGEDY SPWADRKAAQ PKSLSPPQSQ SKLSDSYSNT LPVRKSVTPKNSYATTAENK TLPRSSSMAA GLERNGRMRV KAIFSHAAGD NSTLLSFKEG DLITLLVPEA RDGWHYGESEKTKMRGWFPF SYTRVLDSDG SDRLHMSLQQ GKSSSTGNLLDKDDLAIPPP DYGAASRAFP AQTASGFKQR PYSVAVPAFS QGLDDYGARS MSSGSGTLVS TVVEHHHHHH
• Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: Adherensjunction; CDC42 signaling events; ErbB1 downstream signaling; RAC1 signalingpathway; Regulation of Actin Cytoskeleton

Gene Information

• Gene Name: BAIAP2 BAI1-associated protein2 [ Homo sapiens ]
• Official Symbol: BAIAP2
• Synonyms: BAIAP2;BAI1-associated protein 2; BAP2; FLAF3; IRSP53 brain-specificangiogenesis inhibitor 1-associated protein 2; IRS-58; IRSp53/58; fasligand-associated factor 3; insulin receptor substrate p53/p58; insulinreceptor substrate protein of 53 kDa
• Gene ID: 10458
• mRNA Refseq: NM_001144888
• Protein Refseq: NP_001138360
• MIM: 605475
• UniProt ID: Q9UQB8
• Chromosome Location: 17q25
• Function: SH3domain binding; cytoskeletal adaptor activity ; proline-rich region binding ;protein C-terminus binding ; protein binding