Recombinant Human B-cell CLL/lymphoma 6

• Cat.No.: BCL6-148H
• Product Overview: Recombinant human Bcl-6 protein encoding 1-150aa expressed in E.coli., 43kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-150 a.a.
• Description: Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin’s lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt’s lymphomas and in nodular, lymphocyte predominant Hodgkin’s disease.
• Purity: Greater than 90% by SDS-PAGE.
• Presentation: Recombinant human 100μl purified human Bcl-6 protein at 100μg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol
• Applications: •ELISA •Inhibition Assays •Western Blotting
• Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 43kDa.
• Activity: Not known
• Storage: Store vial at -20℃ to -80℃. When stored at the recommended temperature, this protein is stable for 12 months.

Gene Information

• Gene Name: BCL6 B-cell CLL/lymphoma 6 [ Homo sapiens ]
• Synonyms: BCL-5; BCL-6; BCL6A; LAZ3; ZBTB27; ZNF51; B-cell CLL/lymphoma 6; B-cell lymphoma 6 protein; B-cell lymphoma 6 protein transcript; LAZ-3 protein; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51; Cys-his2 zinc finger transcription factor;Lymphoma-associated zinc finger gene on chromosome 3; Zinc finger transcription factor BCL6S
• Gene ID: 604
• mRNA Refseq: NM_001130845
• Protein Refseq: NP_001124317
• MIM: 109565
• UniProt ID: P41182
• Chromosome Location: 3q27
• Function: Chromatin DNA binding; Metal ion binding; Protein binding; Sequence-specific DNA binding; Transcription factor activity; Transcription repressor activity; Transcription repressor activity; Zinc ion binding