Recombinant Human AZU1 Protein (Pro23-Gly247), His tagged

• Cat.No.: AZU1-0724H
• Product Overview: Recombinant human AZU1 (Pro23-Gly247) fused with His tag was expressed in E. coli.

Specification

• Description: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E. coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 25.78 kDa
• Protein length: Pro23-Gly247
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles.
  Store at 2 to 8 centigrade for one week.
  Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: AZU1 azurocidin 1 [ Homo sapiens (human) ]
• Official Symbol: AZU1
• Synonyms: AZU1; azurocidin 1; azurocidin; AZAMP; AZU; CAP37; cationic antimicrobial protein 37; HBP; heparin binding protein; HUMAZUR; NAZC; neutrophil azurocidin; heparin-binding protein; cationic antimicrobial protein CAP37
• Gene ID: 566
• mRNA Refseq: NM_001700
• Protein Refseq: NP_001691
• MIM: 162815
• UniProt ID: P20160