Recombinant Human AXIN2, GST-tagged

• Cat.No.: AXIN2-10085H
• Product Overview: Recombinant Human AXIN2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 30-83a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: AXIN2 axin 2 [ Homo sapiens ]
• Official Symbol: AXIN2
• Synonyms: AXIN2; axin 2; axin-2; axil; conductin; DKFZp781B0869; MGC126582; axin-like protein; axis inhibition protein 2; AXIL; MGC10366
• Gene ID: 8313
• mRNA Refseq: NM_004655
• Protein Refseq: NP_004646
• MIM: 604025
• UniProt ID: Q9Y2T1
• Chromosome Location: 17q23-q24
• Pathway: Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Canonical Wnt signaling pathway, organism-specific biosystem; Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Endometrial cancer, organism-specific biosystem; Endometrial cancer, conserved biosystem
• Function: GTPase activator activity; I-SMAD binding; armadillo repeat domain binding; beta-catenin binding; beta-catenin binding; enzyme binding; protein kinase binding; signal transducer activity; ubiquitin protein ligase binding