AXIN2
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Official Full Name
axin 2 -
Overview
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] -
Synonyms
AXIN2;axin 2;AXIL;ODCRCS;axin-2;conductin;axin-like protein;axis inhibition protein 2
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Rat
- E. coli
- Wheat Germ
- Mammalian Cells
- E.Coli/Yeast
- E.coli
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AXIN2-10085H | Recombinant Human AXIN2 protein, GST-tagged | E. coli | Human | GST | ||
| AXIN2-1048H | Recombinant Human AXIN2 protein, GST-tagged | Wheat Germ | Human | GST |
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| AXIN2-2221M | Recombinant Mouse AXIN2 Protein | Mammalian Cells | Mouse | His |
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| Axin2-3794M | Recombinant Mouse Axin2, His-tagged | E.Coli/Yeast | Mouse | His | 840 |
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| AXIN2-3796H | Recombinant Human AXIN2, His-tagged | E.coli | Human | His | 843 |
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| AXIN2-6061C | Recombinant Chicken AXIN2 | Mammalian Cells | Chicken | His |
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| AXIN2-9104Z | Recombinant Zebrafish AXIN2 | Mammalian Cells | Zebrafish | His |
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| AXIN2-910R | Recombinant Rat AXIN2 Protein | Mammalian Cells | Rat | His |
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| AXIN2-8554HCL | Recombinant Human AXIN2 293 Cell Lysate | HEK293 | Human | Non |
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| AXIN2-1066HF | Recombinant Full Length Human AXIN2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 160 amino acids |
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| AXIN2-1786H | Recombinant Human AXIN2 protein, His-tagged | E. coli | Human | His |
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| AXIN2-391H | Recombinant Human AXIN2 Protein, His-tagged | E.coli | Human | His | Pro350~Lys631 |
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| AXIN2-566R | Recombinant Rat AXIN2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| AXIN2-566R-B | Recombinant Rat AXIN2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| AXIN2-917M | Recombinant Mouse AXIN2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| AXIN2-917M-B | Recombinant Mouse AXIN2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
AXIN2 involved in several pathways and played different roles in them. We selected most pathways AXIN2 participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with AXIN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | SFRP4,PPARD,CACYBP,WNT5B,WNT16,RAC1A,LEF1,MAP3K7,AXIN1,WNT7B |
| Hippo signaling pathway | CTNNA2,PPP1CA,GDF6,BMP8A,DVL3,WNT8A,FRMD6,TP73,LLGL2,INADL |
| Basal cell carcinoma | WNT2B,FZD8,WNT5B,DVL2,FZD1,Shh,WNT7A,LEF1,TP53,WNT11 |
| Signaling pathways regulating pluripotency of stem cells | PIK3R1,MAPK13,BMP2,BMI1,FZD8,MAPK12,WNT7B,WNT6,MAP2K1,INHBB |
| Colorectal cancer | TGFBR2,MAP2K1,TGFB3,RAC2,PIK3R1,MSH6,MAPK10,PIK3CB,PIK3CD,APPL1 |
| Pathways in cancer | MSH2,SMO,ARNT2,PRKCB,LAMA2,WNT10B,RET,PGF,FN1,AKT2 |
| Endometrial cancer | PIK3CA,PIK3R5,SOS1,MAP2K2,BAD,APC,ERBB2,PTEN,PIK3CB,NRAS |
Protein Function
AXIN2 has several biochemical functions, for example, GTPase activator activity,I-SMAD binding,armadillo repeat domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AXIN2 itself. We selected most functions AXIN2 had, and list some proteins which have the same functions with AXIN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | PINK1,PARK2,RNF34,WASH1,XRCC5,GSK3B,AXIN1,UBE2V2,HSPA1L,NDUFS2 |
| I-SMAD binding | AXIN1,SMAD6,SMAD1,TGFB1I1,TGFBR1,CTNNB1,SMURF1,SMAD7,SMAD2,SMAD4 |
| enzyme binding | UGT1A6B,TSPAN15,CAT,CABYR,SLC18A1,STC2,XRCC1,CAV1,FAM84B,UGT1A6A |
| protein binding | SPC25,PRMT6,Tnfrsf23,CTNNAL1,PLG,PDIA4,NBR1,HRG,BNIP3L,NR1H2 |
| GTPase activator activity | TBC1D21,ARHGDIG,DLC1,RGS10,RIC8,PGAM5,ARHGAP28,STXBP5A,SIPA1L2,SRGAP1 |
| protein kinase binding | CDKN2D,FGFR1OP,ITGB1BP1,TRAF3,YWHAZ,NPR1,BAG5,CAMK2N1,CDK5RAP1,XBP1 |
| beta-catenin binding | CDH5,C,TCF7L1B,PTPRK,FAM123B,MED12L,PTPRU,CDH1,TAX1BP3,SLC9A3R2 |
| armadillo repeat domain binding | TCF7L2,STRN4,CTNNBIP1,CNOT1,AXIN1,LEF1,CHD8,STRN,CALCOCO1 |
Interacting Protein
AXIN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AXIN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AXIN2.
PPP2CB;GSK3B;AMER3;AMMECR1;CDC20;FBP2;ZNF189;TGFB1;NS;FBP1;RANGAP1;PRDX1;SMAD1;HEMGN
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References
- Valenti, F; Ibetti, J; et al. The Increase in Maternal Expression of axin1 and axin2 Contribute to the Zebrafish Mutant Ichabod Ventralized Phenotype. JOURNAL OF CELLULAR BIOCHEMISTRY 116:418-430(2015).
- Mastri, M; Shah, Z; et al. Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 306:C531-C539(2014).
