Recombinant Human Aurora Kinase C, GST-tagged

• Cat.No.: AURKC-990H
• Product Overview: Recombinant full-length human AURKC was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: AURKC is a member of mitotic serine/threonine kinases that regulate centrosome maturation, chromosome segregation, and cytokinesis. AURKC has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumors. AURKC overexpression has been correlated with centrosome amplification, which can be a driving cause of genomic instability in tumor cells. AURKC is an important regulator of both genomic integrity and cell cycle progression in cancer cells and is an attractive target for anticancer drug development.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 61 kDa
• Expression System: Sf9 insect cells using baculovirus
• Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25 % glycerol.
• Specific Activity: 65 nmol/min/mg
• Purity: > 80 %
• Concentration: 0.1 ug/ul
• Sequences: Full-length
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Aurora B signaling; Aurora C signaling; Signaling by Aurora kinases

Gene Information

• Gene Name: AURKC aurora kinase C [ Homo sapiens ]
• Official Symbol: AURKC
• Synonyms: AURKC; aurora kinase C; AIE2; AIK3; ARK3; AurC; STK13; aurora-C; serine/threonine-protein kinase 13; ARK-3; aurora-related kinase 3; aurora/IPL1/EG2 protein 2; aurora/IPL1-related kinase 3; serine/threonine-protein kinase aurora-C; serine/threonine kinase 13 (aurora/IPL1-like); Aurora-C
• Gene ID: 6795
• mRNA Refseq: NM_003160
• Protein Refseq: NP_003151
• MIM: 603495
• UniProt ID: Q5Y191
• Chromosome Location: 19q13.43
• Function: ATP binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity