Recombinant Human AURKC
Cat.No. : | AURKC-27499TH |
Product Overview : | Recombinant full length IPL-1/STK13/Aurora C protein (Human), MW ~61 kDa with N terminal enzyme tag, expressed by baculovirus in Sf9 insect cells. |
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Species : | Human |
Tag : | Non |
Description : | This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. |
Tissue specificity : | Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Expression is maximum at M phase. |
Biological activity : | Specific activity 65nmol/min/mg |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.Contains 1 protein kinase domain. |
Full Length : | Full L. |
Gene Name | AURKC aurora kinase C [ Homo sapiens ] |
Official Symbol | AURKC |
Synonyms | AURKC; aurora kinase C; serine/threonine kinase 13 (aurora/IPL1 like) , STK13; ARK3; AurC; |
Gene ID | 6795 |
mRNA Refseq | NM_001015878 |
Protein Refseq | NP_001015878 |
MIM | 603495 |
Uniprot ID | Q9UQB9 |
Chromosome Location | 19q13.3-qter |
Pathway | Aurora B signaling, organism-specific biosystem; Aurora C signaling, organism-specific biosystem; Signaling by Aurora kinases, organism-specific biosystem; |
Function | ATP binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; |
◆ Recombinant Proteins | ||
AURKC-1115H | Recombinant Human AURKC Protein (S2-S309), GST tagged | +Inquiry |
AURKC-1060HF | Recombinant Full Length Human AURKC Protein, GST-tagged | +Inquiry |
AURORA C-3779H | Recombinant Human AURORA C protein, GST-tagged | +Inquiry |
AURKC-1114H | Recombinant Human AURKC Protein (S2-S309), Tag Free | +Inquiry |
AURKC-27499TH | Recombinant Human AURKC | +Inquiry |
◆ Cell & Tissue Lysates | ||
AURKC-8559HCL | Recombinant Human AURKC 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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