Recombinant Human Aurora Kinase B

• Cat.No.: AURKB-5292H
• Product Overview: RecombinantHuman AURKB expressed in a cell expression system.

Specification

• Cat. No.: AURKB-5292H
• Description: AURKB is aprotein that functions in the attachment of the mitotic spindle to thecentromere. Chromosomal segregation during mitosis as well as meiosis isregulated by kinases and phosphatases. The Aurora kinases associate withmicrotubules during chromosome movement and segregation. AURKB localizesto microtubules near kinetochores, specifically to the specializedmicrotubules called K-fibers, and Aurora kinase A localizes to centrosomes.
• Source: Sf9 cells
• Species: Human
• Purity: Greater than 95% bySDS-PAGE.
• Form: 25 mM Tris-HCl, pH8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, 3 mM DTT.
• Storage: 6 months at -80°C.
• OfficialSymbol: AURKB
• Tag: Non

Gene Information

• Gene Name: AURKB aurora kinase B [ Homosapiens ]
• Synonyms: AURKB; aurora kinaseB; AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1;STK12; PPP1R48; aurkb-sv1; aurkb-sv2; aurora kinase B; ARK-2; STK-1; aurora 1;aurora-1; aurora-B; OTTHUMP00000135331; aurora kinase B-Sv1; aurora kinaseB-Sv2; aurora-related kinase 2; serine/threonine kinase 12;aurora/IPL1-related kinase 2; serine/threonine-protein kinase 5;serine/threonine-protein kinase 12; serine/threonine-protein kinase aurora-B;protein phosphatase 1, regulatory subunit 48; aurora- and Ipl1-likemidbody-associated protein 1
• Gene ID: 9212
• mRNA Refseq: NM_004217
• Protein Refseq: NP_004208
• MIM: 604970
• UniProt ID: Q96GD4
• Chromosome Location: 17p13.1
• Pathway: APC/C-mediateddegradation of cell cycle proteins; APC/C:Cdh1 mediated degradation of Cdc20and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Aurora Asignaling; Aurora B signaling; Aurora C signaling; Cell Cycle; DNAReplication; FOXM1 transcription factor network; M Phase; Mitotic M-M/G1phases; Mitotic Prometaphase; Regulation of mitotic cell cycle; Signaling byAurora kinases
• Function: ATP binding; metalion binding; nucleotide binding; protein binding; protein serine/threoninekinase activity; protein serine/threonine/tyrosine kinase activity