AURKB
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Official Full Name
aurora kinase B -
Overview
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013] -
Synonyms
AURKB;aurora kinase B;AIK2;AIM1;ARK2;AurB;IPL1;STK5;AIM-1;STK12;PPP1R48;aurkb-sv1;aurkb-sv2;ARK-2;STK-1;aurora 1;aurora-1;aurora-B;aurora kinase B-Sv1;aurora kinase B-Sv2;aurora-related kinase 2;serine/threonine kinase 12;aurora/IPL1-related kinase 2;serine/threonine-protein kinase 5;serine/threonine-protein kinase 12;serine/threonine-protein kinase aurora-B;protein phosphatase 1, regulatory subunit 48;aurora- and Ipl1-like midbody-associated protein 1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Wheat Germ
- Mammalian Cells
- Sf9 Cells
- Insect Cells
- E.Coli/Yeast
- HEK293
- In Vitro Cell Free System
- Sf21 Cells
- His
- GST
- Non
- Flag&His
- DDK&Myc
- Flag
- Avi&Fc&His
Involved Pathway
AURKB involved in several pathways and played different roles in them. We selected most pathways AURKB participated on our site, such as APC/C-mediated degradation of cell cycle proteins,APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1,Aurora A signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AURKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | CKAP5,NIPBL,RAD1,CEP152,MIS12,TUBGCP4,SMC2,RNF168,CDKN1B,CEP135 |
| Aurora C signaling | INCENP,AURKC |
| Cell Cycle, Mitotic | VRK1,MAPRE1A,TUBB4B,FGFR1OP,TMPO,PMF1,CEP152,CP110,CENPE,CDKN1B |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | UBE2C,PSMD5,ANAPC10,PSMD14,PSMD9,PSMD10,PSMA8,PSME3 |
| Aurora B signaling | PEBP1,KIF20A,NCAPD2,NDC80,CDCA8,SMC4,DES,AURKC,NPM1,INCENP |
| FOXM1 transcription factor network | CKS1B,CHEK2,FOXM1,CENPA,CENPB |
| Aurora A signaling | GADD45A,NDEL1,TACC3,TDRD7,TPX2,TACC1,OAZ1,AURKAIP1,CENPA |
| APC/C-mediated degradation of cell cycle proteins | ANAPC10,PSMD9,UBE2C,PSMD10,PSMD14,NEK2,CDK2,PSME3,PSMA8,PSMD5 |
Protein Function
AURKB has several biochemical functions, for example, ATP binding,histone serine kinase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AURKB itself. We selected most functions AURKB had, and list some proteins which have the same functions with AURKB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RFPL3,TMEM14C,G3BP2,MX2,C21orf7,PARK7,KIR2DL4,STX1A,ACACB,PCK2 |
| ATP binding | BRAF,MYO1EB,IRAK3,CNTN1B,SRPK1B,XYLB,ATP6V1A,NPR2,TAP2,ACVR2AA |
| metal ion binding | ZNF562,ZFP12,APLF,SHRPRBCK1R,PGGT1B,IKZF2,Reln,RPP21,CA,LRRK1 |
| protein serine/threonine/tyrosine kinase activity | TESK2,DSTYK,DYRK3,AURKA,RPS6KB1,CLK3,AURKC,SGK1,CLK2,TTK |
| protein serine/threonine kinase activity | CAMK1GA,TSSK5,RIPK4,DMPK,SMG1,PRKACBB,STK39,OXSR1B,BMPR2B,MINK1 |
| histone serine kinase activity | ATM,PRKAA2,AURKC,AURKA,PRKAA1 |
Interacting Protein
AURKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AURKB here. Most of them are supplied by our site. Hope this information will be useful for your research of AURKB.
BIRC5;INCENP;SEPT1
Resources
Research Area
Cancer Drug TargetsHistone Phosphorylation
Microtubules
Metaphase (Mitotic Spindle) Checkpoints
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References
