Recombinant Human ATXN10 protein, His & T7-tagged

• Cat.No.: ATXN10-7957H
• Product Overview: Recombinant Human ATXN10 aa. (Leu116~Ala302 (Accession # Q9UBB4)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Description: This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.
• Source: E. coli
• Species: Human
• Tag: His&T7
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 25.2kDa
• Protein length: Leu116~Ala302
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 4.7.
• Applications: SDS-PAGE; WB; ELISA; IP
• Stability: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage Buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: ATXN10 ataxin 10 [ Homo sapiens (human) ]
• Official Symbol: ATXN10
• Synonyms: ATXN10; ataxin 10; E46L; SCA10; HUMEEP; ataxin-10; brain protein E46 homolog; spinocerebellar ataxia type 10 protein
• Gene ID: 25814
• mRNA Refseq: NM_001167621.1
• Protein Refseq: NP_001161093.1
• UniProt ID: Q9UBB4