Recombinant Human ATOX1 (Yeast) (Lyophilized)

• Cat.No.: ATOX1-451H
• Product Overview: Recombinant Human full length HAH1 (Copper transport protein ATOX1, Metal transport protein ATX1) cloned from human cDNA with a C-terminal purification tag was expressed inE.coli.The protein consists of the human HAH1 (residues 1-68, swissprot O00244). The C-terminal tag is cleaved during purification. MW = 7.8 kDa.

Specification

• Cat. No.: ATOX1-451H
• Description: Copper transport protein ATOX1 is a protein that in humans is encoded by the ATOX1 gene. This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. In melanocytic cells ATOX1 gene expression may be regulated by MITF.
• Source: Escherichia Coli.
• Purity: > 95% by SDS-PAGE. The protein was observed as a single band migrating at amolecular weight of (<10 kDa).
• Supplied As: Lyophilized from a 1mg/ml solution containing 1mM DTT (1ml). The concentration is calculated from the absorbance at 280nm (e280= 2680 M-1 cm-1).
• Characteristics: Under the above described conditions, to avoid precipitation or protein dimerization, the product can be concentrated to a maximum of 1mM. In case of precipitation, the precipitate can be partially redissolved using buffer solution with high conc. of DTT (20mM or more).
• Storage: -20ºC. The protein is stable at 4ºC for at least 2 weeks and at 25ºC for at least several hours. After initial defrost, aliquot product into individual tubes and refreeze at -20ºC. Avoid repeated freeze/defrost cycles.
• Tag: Non
• Protein length: 1-68 a.a.
• Full Length: Full L.

Gene Information

• Gene Name: ATOX1 ATX1 antioxidant protein 1 homolog (yeast) [ Homo sapiens ]
• Synonyms: ATOX1; ATX1 antioxidant protein 1 homolog (yeast); ATX1; HAH1; MGC138453; MGC138455; antioxidant protein 1; metal transport protein; copper transport protein; ATX1 (antioxidant protein 1, yeast) homolog 1; Copper transport protein ATOX1; Metal transport protein ATX1
• Gene ID: 475
• mRNA Refseq: NM_004045
• Protein Refseq: NP_004036
• MIM: 2270
• UniProt ID: O00244
• Chromosome Location: 5q32
• Function: copper chaperone activity; copper-dependent protein binding; metal ion binding