Recombinant Human ASZ1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ASZ1-2378H
• Product Overview: ASZ1 MS Standard C13 and N15-labeled recombinant protein (NP_570124) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 53.5 kDa
• AA Sequence: MAASALRGLPVAGGGESSESEDDGWEIGYLDRTSQKLKRLLPIEEKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNPLEGKLQQLTKEDTICKILTTDSDREKDHIFSSYTAFGDLEVFLHGLGLEHMTDLLKERDITLRHLLTMREDEFTKNGITSKDQQKILAALKELQVEEIQFGELSEETKLEISGDEFLNFLLKLNKQCGHLITAVQNVITELPVNSQKITLEWASPQNFTSVCEELVNNVEDLSEKVCKLKDLIQKLQNERENDPTHIQLREEVSTWNSRILKRTAITICGFGFLLFICKLTFQRKTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 [ Homo sapiens (human) ]
• Official Symbol: ASZ1
• Synonyms: ASZ1; ankyrin repeat, SAM and basic leucine zipper domain containing 1; ANKL1, ankyrin like 1, C7orf7; ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; ALP1; CT1.19; GASZ; Orf3; 4933400N19Rik; ankyrin-like 1; ankyrin-like protein 1; germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein; ANKL1; C7orf7; MGC26634
• Gene ID: 136991
• mRNA Refseq: NM_130768
• Protein Refseq: NP_570124
• MIM: 605797
• UniProt ID: Q8WWH4