Recombinant Human ASIP Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ASIP-4038H
• Product Overview: ASIP MS Standard C13 and N15-labeled recombinant protein (NP_001663) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 14.52 kDa
• AA Sequence: MDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDVPSVSIVALNKKSKQIGRKAAEKKRSSKKEASMKKVVRPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNCTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ASIP agouti signaling protein [ Homo sapiens (human) ]
• Official Symbol: ASIP
• Synonyms: ASIP; agouti signaling protein; ASP; AGSW; AGTI; AGTIL; SHEP9; agouti-signaling protein; agouti signaling protein, nonagouti homolog; agouti switch protein; nonagouti homolog
• Gene ID: 434
• mRNA Refseq: NM_001672
• Protein Refseq: NP_001663
• MIM: 600201
• UniProt ID: P42127