Recombinant Human ASH2L Protein, SUMO-tagged

• Cat.No.: ASH2L-159H
• Product Overview: Recombinant human ASH2L protein was expressed in E. coli with a SUMO tag.

Specification

• Description: Transcriptional regulator. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May play a role in hematopoiesis. In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B.
• Source: E. coli
• Species: Human
• Tag: SUMO
• Molecular Mass: 60.1 kDa
• Purity: ≥90%
• Unit Definition: Activity was demonstrated by a radiometric assay of the MLL1 complex (ASH2L, WDR5, RbBP5, and MLL1) and MLL1 complex (ASH2L, WDR5, RbBP5, MLL1, and DPY30) using [3H]-S-adenosylmethionine and Core Histones which specifically methylates Histone H3.
• Storage Buffer: 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol

Gene Information

• Gene Name: ASH2L ASH2 like, histone lysine methyltransferase complex subunit [ Homo sapiens (human) ]
• Official Symbol: ASH2L
• Synonyms: ASH2L; ASH2 like, histone lysine methyltransferase complex subunit; ASH2; Bre2; ASH2L1; ASH2L2; set1/Ash2 histone methyltransferase complex subunit ASH2; ASH2-like protein; ash2 (absent, small, or homeotic)-like
• Gene ID: 9070
• mRNA Refseq: NM_004674
• Protein Refseq: NP_004665
• MIM: 604782
• UniProt ID: Q9UBL3