Recombinant Human ARRB1 Protein, N-His-tagged

• Cat.No.: ARRB1-11H
• Product Overview: Purified recombinant protein of Human arrestin, beta 1 (ARRB1), transcript variant 1,full length, with N-terminal His tag, expressed in E. coli.

Specification

• Description: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 50mM Tris, 8M Urea, pH8.0.
• Molecular Mass: 46.9 kDa
• AA Sequence: A DNA sequence encoding the full length of ARRB1.
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Applications: Cell culture: For culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Full Length: Full L.

Gene Information

• Gene Name: ARRB1 arrestin beta 1 [ Homo sapiens (human) ]
• Official Symbol: ARRB1
• Synonyms: ARB1; ARR1
• Gene ID: 408
• mRNA Refseq: NM_004041.5
• Protein Refseq: NP_004032.2
• MIM: 107940
• UniProt ID: P49407