Recombinant Human ApoE3

• Cat.No.: ApoE3-3562H
• Product Overview: ApoE3

Specification

• Description: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
• Source: E. Coli
• Species: Human
• Form: Lyophilized
• Molecular Mass: 36,154 Da
• Protein length: 317
• Purity: >90% by SDS-PAGE & HPLC analyses
• Notes: Small volumes of ApoE3 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.
• Tag: Non

Gene Information

• Gene Name: ApoE3
• Official Symbol: ApoE3
• Synonyms: APOE; APOE; AD2; LPG; LDLCQ5; Apo-E
• Gene ID: 348
• mRNA Refseq: NM_000041.2
• Protein Refseq: NP_000032.1
• MIM: 104310
• UniProt ID: P02649
• Chromosome Location: Chromosome: 19; NC_000019.10 (44905782..44909393). Location: 19q13.2
• Function: ?ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants