Recombinant Human APOA5, Protein A-tagged

• Cat.No.: APOA5-26876TH
• Product Overview: Recombinant full-length Human Apolipoprotein A V with C-Terminal DDDDK tag.

Specification

• Description: The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified.
• Protein length: 343 amino acids
• Conjugation: FLAG
• Molecular Weight: 40.100kDa inclusive of tags
• Source: HEK 293 cells
• Tissue specificity: Liver and plasma.
• Form: Lyophilised:Add deionized water (200 μl) to prepare a working stock solution of 0.5 mg/mL
• Purity: by SDS-PAGE
• Storage buffer: pH: 7.50Constituents:0.24% Tris, 0.29% Sodium chloride
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: RKGFWDYFSQ TSGDKGRVEQ IHQQKMAREP ATLKDSLEQD LNNMNKFLEK LRPLSGSEAP RLPQDPVGMR RQLQEELEEV KARLQPYMAE AHELVGWNLE GLRQQLKPYT MDLMEQVALR VQELQEQLRV VGEDTKAQLL GGVDEAWALL QGLQSRVVHH TGRFKELFHP YAESLVSGIG RHVQELHRSV APHAPASPAR LSRCVQVLSR KLTLKAKALH ARIQQNLDQL REELSRAFAG TGTEEGAGPD PQMLSEEVRQ RLQAFRQDTY LQIAAFTRAI DQETEEVQQQ LAPPPPGHSA FAPEFQQTDS GKVLSKLQAR LDDLWEDITH SLHDQGHSHL GDPAAADYKD DDDK
• Sequence Similarities: Belongs to the apolipoprotein A1/A4/E family.

Gene Information

• Gene Name: APOA5 apolipoprotein A-V [ Homo sapiens ]
• Official Symbol: APOA5
• Synonyms: APOA5; apolipoprotein A-V; APOA V; RAP3
• Gene ID: 116519
• mRNA Refseq: NM_001166598
• Protein Refseq: NP_001160070
• MIM: 606368
• Uniprot ID: Q6Q788
• Chromosome Location: 11q23
• Pathway: Chylomicron-mediated lipid transport, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Lipid digestion, mobilization, and transport, organism-specific biosystem; Lipoprotein metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem
• Function: enzyme activator activity; enzyme binding; heparin binding; contributes_to heparin binding; lipase activator activity