APOA5
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Official Full Name
apolipoprotein A-V -
Overview
Apolipoproteins are proteins that bind lipids (oil-soluble substances such as fat and cholesterol) to form lipoproteins. They transport the lipids through the lymphatic and circulatory systems. The lipid components of lipoproteins are insoluble in water. However, because of their detergent-like (amphipathic) properties, apolipoproteins and other amphipathic molecules (such as phospholipids) can surround the lipids, creating the lipoprotein particle that is itself water-soluble, and can thus be carried through water-based circulation (i.e., blood, lymph). Apolipoproteins also serve as enzyme cofactors, receptor ligands, and lipid transfer carriers that regulate the metabolism of lipoproteins and their uptake in tissues. -
Synonyms
UNQ411/PRO773;APOAV;RAP3;apo-AV;apolipoprotein A5;regeneration-associated protein 3
Recombinant Proteins
- Human
- Mouse
- Rat
- Cattle
- Chicken
- Guinea pig
- Pig
- Rabbit
- E.coli
- HEK293
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- His
- Flag
- GST
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
APOA5 involved in several pathways and played different roles in them. We selected most pathways APOA5 participated on our site, such as Chylomicron-mediated lipid transport,Fatty acid, triacylglycerol, and ketone body metabolism,Lipid digestion, mobilization, and transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | NUDT5,SLC5A9,SLC35B2,PYGMB,B3GNT2,CEPT1A,ADSSL1,SLC25A11,IDO2,B3GNT2A |
| PPARA activates gene expression | CDK19,G0S2,MED22,MED23,GRHL1,MED31,MED19,MED18,MED29,MED6 |
| Lipoprotein metabolism | APOA4B.1,ABCA1,CETP,MTP,APOA1B,APOA4A,APOC2,APOA4B.2,Alb,APOBB.1 |
| Chylomicron-mediated lipid transport | APOC2,APOA4A,APOEA,APOA1B,APOA4B.2,APOA4B.1,APOBB.1,MTP,APOEB |
| PPAR signaling pathway | ACSL3A,CYP4A10,LPL,SLC27A5,APOA2,PPARD,PPARAB,SLC27A4,ACADL,ANGPTL4 |
| Metabolism of lipids and lipoproteins | STARD5,NFYBA,CYP4F22,CPNE6,CPT2,GGTLC1,MED9,SACM1LB,FABP9,CDK19 |
| Lipid digestion, mobilization, and transport | LPA,APOEA,FABP11B,FABP1B.1,FABP12,APOA4B.2,LMF2,APOA4B.1,APOBB.1,APOEB |
| Fatty acid, triacylglycerol, and ketone body metabolism | GLIPR1,ELOVL1A,ACSF2,CDK8,ACOT6,SLC25A1,MMAA,AGPAT6,YAP1,AGT |
Protein Function
APOA5 has several biochemical functions, for example, cholesterol binding,cholesterol transporter activity,enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APOA5 itself. We selected most functions APOA5 had, and list some proteins which have the same functions with APOA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cholesterol transporter activity | APOA4B.1,CETP,ABCA1,ABCG1,APOB,ABCA1B,APOE,ABCA7,ABCA4,ABCA4A |
| low-density lipoprotein particle receptor binding | APOEA,AP2M1,SLC9A3R2,HSP90B1,SACS,DKK1,CRP,PCSK9,APOE,ARRB2 |
| enzyme activator activity | TRIM23,MMP15,CLPSL1,MMP16,PSAP,CLPS,ALDH1A2,UBA2,OGT,SFTPB |
| enzyme binding | MLL5,CYP3A4,TOP2A,HSPA8,UGT1A7,FOXO4,PYCARD,CD40,CBX1,HMGA1-RS1 |
| cholesterol binding | APOA1,APOE,CYP11A1,APOA4,APOA4B.1,STAR,STARD3,STARD6,SCP2,NPC2 |
| phospholipid binding | APOE,NOXO1,ARHGAP44,PACSIN1A,APOEB,SEC14L2,NSFL1C,SYTL4,PLA2G4C,TICAM2 |
| phosphatidylcholine-sterol O-acyltransferase activator activity | APOA2,APOEA,APOE,APOA1A,APOA4B.1,APOC1,APOEB,APOA4B.2,APOA1,APOA4A |
| lipoprotein lipase activator activity | APOC2,APOH |
| lipid binding | ATP5G1,PLUNC,FAM123C,ACBD6,ACBD5A,PITPNC1,ACBD5,FFAR1,CYTH2,ANXA6 |
Interacting Protein
APOA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOA5.
LPL;LPL;FAS;RAB5B;SMARCD1;q99ib8-pro_0000045598
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References
- Ashraf, AP; Beukelman, T; et al. Type 1 Hyperlipoproteinemia and Recurrent Acute Pancreatitis due to Lipoprotein Lipase Antibody in a Young Girl with Sjogren's Syndrome. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 96:3302-3307(2011).
- Chen, Q; Reis, SE; et al. Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study. JOURNAL OF LIPID RESEARCH 52:801-807(2011).
