Recombinant Human APOA5, His-tagged

• Cat.No.: APOA5-9750H
• Product Overview: Recombinant Human APOA5 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 27-366a.a.
• Description: The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: APOA5 apolipoprotein A-V [ Homo sapiens ]
• Official Symbol: APOA5
• Synonyms: APOA5; apolipoprotein A-V; APOA V; RAP3; apo-AV; apolipoprotein A5; regeneration-associated protein 3; APOAV; FLJ97995; MGC126836; MGC126838
• Gene ID: 116519
• mRNA Refseq: NM_001166598
• Protein Refseq: NP_001160070
• MIM: 606368
• UniProt ID: Q6Q788
• Chromosome Location: 11q23
• Pathway: Chylomicron-mediated lipid transport, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Lipid digestion, mobilization, and transport, organism-specific biosystem; Lipoprotein metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; PPAR signaling pathway, organism-specific biosystem
• Function: enzyme activator activity; enzyme binding; heparin binding; contributes_to heparin binding; lipase activator activity; lipid binding; lipoprotein lipase activator activity; lipoprotein particle receptor binding; low-density lipoprotein particle receptor b