Recombinant Human Annexin A1, T7-tagged

• Cat.No.: ANXA1-5277H
• Product Overview: Recombinant HumanANXA1 (aa 1-346) was expessed in E. coli including a His tag. Its molecularweight is 41430 Dalton.

Specification

• Species: Human
• Source: E.coli
• Tag: T7
• Protein Length: 1-346 a.a.
• Description: ANXA1 belongs to a familyof Ca(2+)-dependent phospholipid binding proteins which have a molecularweight of approximately 35,000 to 40,000 and are preferentially located onthe cytosolic face of the plasma membrane. ANXA1 protein has an apparentrelative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity.Since phospholipase A2 is required for the biosynthesis of the potentmediators of inflammation, prostaglandins and leukotrienes, ANXA1 may havepotential anti-inflammatory activity.
• Form: Liquid in 20 mMTris-HCl + 0.5 M NaCl + 100 mM imidazole + 1 mM 2-mercaptoethanol, pH 8.
• Molecular Weight: 41.43 kDa
• Applications: ELISA; Western Blot;Antibody Production; Protein array
• OfficialSymbol: ANXA1

Gene Information

• Gene Name: ANXA1 annexin A1 [ Homosapiens ]
• Synonyms: ANXA1; annexin A1;ANX1; LPC1; Annexin A1; Annexin-1; Annexin I; Lipocortin I; Calpactin II;Chromobindin-9; p35; Phospholipase A2 inhibitory protein; OTTHUMP00000021475;OTTHUMP00000021474; annexin A1; annexin I (lipocortin I); annexin-1;calpactin-2; lipocortin I; chromobindin-9; phospholipase A2 inhibitoryprotein; annexin A1; Calpactin-2
• Gene ID: 301
• mRNA Refseq: NM_000700
• Protein Refseq: NP_000691
• MIM: 151690
• UniProt ID: P04083
• Chromosome Location: 9q12-q21.2; 9q21.13
• Pathway: Class A/1(Rhodopsin-like receptors); Formyl peptide receptors bind formyl peptides andmany other ligands; G alpha (i) signalling events; G alpha (q) signallingevents; GPCR downstream signaling; GPCR ligand binding; Peptideligand-binding receptors; Prostaglandin Synthesis and Regulation; SignalTransduction; Signaling by GPCR
• Function: calciumion binding; calcium-dependent phospholipid binding; phospholipase A2inhibitor activity; phospholipase inhibitor activity; protein binding,bridging; receptor binding; structural molecule activity; phospholipidbinding; protein binding; protein homodimerization activity; single-strandedDNA binding; single-stranded RNA binding