ANXA1
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Official Full Name
annexin A1 -
Overview
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008] -
Synonyms
ANXA1;annexin A1;ANX1;LPC1;p35;annexin-1;calpactin-2;calpactin II;lipocortin I;chromobindin-9;annexin I (lipocortin I);phospholipase A2 inhibitory protein
Recombinant Proteins
- Pig
- Mouse
- Human
- Cynomolgus
- Rat
- Rabbit
- Guinea pig
- Chicken
- E.coli
- C-His
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- Yeast
- His
- His&S
- Non
- T7
- GST
- Myc&DDK
- Flag
- His&Avi
- His&Fc&Avi
Involved Pathway
ANXA1 involved in several pathways and played different roles in them. We selected most pathways ANXA1 participated on our site, such as Class A/1 (Rhodopsin-like receptors),Formyl peptide receptors bind formyl peptides and many other ligands,G alpha (i) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | APLN,TAC3,EDNRB,NMBB,TAS2R16,NMBA,OPN1SW,ARHGEF1A,SSTR3,RGS11 |
| G alpha (q) signalling events | EDN3,OXTRL,PROKR1,RGS19,CHRM5,TRPC6A,GRP,CHRM1,TRPC3,DGKA |
| Integrated Breast Cancer Pathway | SMARCA4,SELK,GDI1,APOBEC3G,ALKBH1,DHTKD1,DCAKD,JAKMIP1,C21orf7,DAG1 |
| Gastrin-CREB signalling pathway via PKC and MAPK | OPN4B,ANXA1A,FFAR3,UTS2D,TRPC3,GPR132B,TRPC7,DGKA,GPR65,GPR4 |
| Formyl peptide receptors bind formyl peptides and many other ligands | FPR-RS6,FPR-RS3,HEBP1,FPR-RS4 |
| Class A/1 (Rhodopsin-like receptors) | PYY,OPN1LW2,CXCR6,PROKR2,FPR-RS4,GPR68,ADRA1B,NPB,OPN1LW,NMBB |
| GPCR ligand binding | CGA,RGR,SST,OXGR1A.1,QRFP,EDN1,PYY,PROKR1,EDNRA,CD97 |
| G alpha (i) signalling events | DRD4,PYYA,PPY,RGS18,SOUL3,POMCB,RGS7,CCR6,TAS2R13,CCR1 |
Protein Function
ANXA1 has several biochemical functions, for example, annealing helicase activity,calcium ion binding,calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA1 itself. We selected most functions ANXA1 had, and list some proteins which have the same functions with ANXA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | HCST,NCR3,CYTL1,CCL2,ABL2,TYROBP,TDGF1,CX3CL1,Artn,SMAGP |
| single-stranded DNA binding | RPA3,WBP11,MCM10,RAD23A,MLH3,PURA,NABP1,TREX1,XRCC2,HMGB1 |
| calcium ion binding | CANX,CDH11,PCDHGA4,CANT1A,NELL1,CDH8,TBC1D9B,DGKB,RPH3A,EDIL3 |
| phospholipase A2 inhibitor activity | CC10,ANXA2,ANXA3 |
| protein binding, bridging | RBM14,TRIM5,FLRT1,TIRAP,TRIM17,RAD50,CSTA,CBX5,CUX1,NMD3 |
| single-stranded RNA binding | RBMX,DHX58,ZFP36,CNBP,CBX8,PIWIL1,HNRNPF,CBX7,AGO2,LSM14A |
| annealing helicase activity | BLM,SMARCAL1,RAD54L,RECQL,ZRANB3,RECQL4 |
| protein homodimerization activity | MGLL,PTPRE,RAB11FIP4B,PDK2,TRPM8,NADK2,FZD9,ACAT1,ADRA2C,CCDC103 |
| protein binding | NDEL1,IRF5,LCAT,EXOSC5,KL,JAM2,PSMC3,CYP2S1,KLHL38,KCTD9 |
Interacting Protein
ANXA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA1.
EGFR;RIPK1;IKBKG;STK4;PPM1B;NFKBIA;ACTB
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References
- Belvedere, R; Bizzarro, V; et al. Role of intracellular and extracellular annexin A1 in migration and invasion of human pancreatic carcinoma cells. BMC CANCER 14:-(2014).
- Wang, WL; Guan, SL; et al. Detection of circulating antibodies to linear peptide antigens derived from ANXA1 and DDX53 in lung cancer. TUMOR BIOLOGY 35:4901-4905(2014).
