Recombinant Human Angiopoietin-like 7, FLAG-tagged

• Cat.No.: ANGPTL7-410H
• Product Overview: Recombinant Human ANGPTL7 (angiopoietin-like protein 7) (aa 1-346) produced inHEK 293 cellsis fused at the N-terminus to a FLAG-tag.

Specification

• Species: Human
• Source: HEK293
• Tag: Flag
• Protein Length: 1-346 a.a.
• Description: Human ANGPTL7 is produced as a secreted glycoprotein with a molecular mass of 45kDa in SDS-PAGE analysis. Human mRNA is expressed in neural tissues, keratoconus cornea, trabecular meshwork, melanotic melanoma and uterus endometrial cancer, while mouse Angptl7 mRNA is expressed in four-cell embryos, synovial fibroblasts, thymus, uterus and testis. ANGPTL7 reduces tumor growth and aberrant blood vessel formation by inducing massive fibrosis in a mouse xenograft model. It was reported that addition of ANGPTL7 results in a further increase in HSC activities. This suggests that ANGPTL7 may activate signal transduction pathways that cannot be activated by SCF, TPO, IGF-2 or FGF-1. Human ANGPTL7, characterized as potent target gene of WNT/ beta-catenin signalling pathway, is a pharmacogenomics target in the fields of oncology and regenerative medicine.
• Purity: ≥90% (SDS-PAGE).
• Formulation: Liquid. 0.2µm-filtered solution in PBS.
• Concentration: ~0.5mg/ml.
• Endotoxin Content: <0.1EU/µg protein (LAL-test).
• Long Term Storage: -20°C.
• Use/Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
• Handling: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: ANGPTL7 angiopoietin-like 7 [ Homo sapiens ]
• Synonyms: angiopoietin-like 7; AngX; CDT6; dJ647M16.1; RP4-647M16.2; ANGPTL7; angiopoietin-like protein 7; angiopoietin-related protein 7; angiopoietin-like factor (CDT6); cornea-derived transcript 6 protein;Angiopoietin-like factor; Cornea-derived transcript 6 protein
• Gene ID: 10218
• mRNA Refseq: NM_021146
• Protein Refseq: NP_066969
• UniProt ID: O43827
• Chromosome Location: 1p36.3-p36.2
• Function: receptor binding