Recombinant Human ANAPC5, His-tagged
Cat.No. : | ANAPC5-9639H |
Product Overview : | Recombinant Human ANAPC5 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
Availability | March 14, 2025 |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Protein Length : | 1-343a.a. |
Description : | This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name | ANAPC5 anaphase promoting complex subunit 5 [ Homo sapiens ] |
Official Symbol | ANAPC5 |
Synonyms | ANAPC5; anaphase promoting complex subunit 5; anaphase-promoting complex subunit 5; APC5; cyclosome subunit 5; |
Gene ID | 51433 |
mRNA Refseq | NM_001137559 |
Protein Refseq | NP_001131031 |
MIM | 606948 |
UniProt ID | Q9UJX4 |
Chromosome Location | 12q24 |
Pathway | APC/C complex, organism-specific biosystem; APC/C complex, conserved biosystem; APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; |
Function | binding; protein phosphatase binding; ubiquitin-protein ligase activity; |
◆ Recombinant Proteins | ||
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ANAPC5-546H | Recombinant Human ANAPC5 protein, GST-tagged | +Inquiry |
Anapc5-3449R | Recombinant Rat Anapc5, His-tagged | +Inquiry |
ANAPC5-1211H | Recombinant Human ANAPC5 Protein (2-232 aa), GST-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
ANAPC5-74HCL | Recombinant Human ANAPC5 cell lysate | +Inquiry |
Not For Human Consumption!
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