Recombinant Human ALPP

• Cat.No.: ALPP-53H
• Product Overview: Recombinant Human Placental Alkaline Phosphatase encoding 154-287 amino acids expressed inE.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• ProteinLength: 154-287 a.a.
• Description: Placental alkaline phosphatase (PLAP) is a membrane-associated siaglycoprotein enzyme normally present at high concentration in syncytiotrophoblasts within the placenta during the third trimester of gestation. The expression of PLAP was originally thought to be restricted to term placenta but a human PLAP-like variant has been described which shares more than 85% homology with PLAP itself. PLAP is expressed only in normal term placenta, endocervix and fallopian tube and also in ovarian and proximal gastrointestinal tumors. It is also commonly expressed in germ cell tumors and more recently described in seminomas.
• Physical Appearance: Sterile filtered liquid.
• Formulation: PLAP at 100 µg/ml in 50 mM Tris-Acetate, pH7.5, 1 mM EDTA and 20% Glycerol.
• Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 41 kDa.
• Stability: Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: ALPP alkaline phosphatase, placental (Regan isozyme) [ Homo sapiens ]
• Synonyms: ALPP; alkaline phosphatase, placental (Regan isozyme); ALP; PALP; PLAP; FLJ61142; Alkaline phosphatase, placental type;PLAP-1; Alkaline phosphatase Regan isozyme; EC 3.1.3.1; glycerophosphatase; placental alkaline phosphatase; alkaline phosphomonoesterase
• Gene ID: 250
• mRNA Refseq: NM_001632
• Protein Refseq: NP_001623
• UniProt ID: P05187
• Chromosome Location: 2q37
• MIM: 171800
• Pathway: Folate biosynthesis; Metabolic pathways; gamma-Hexachlorocyclohexane degradation
• Function: alkaline phosphatase activity; hydrolase activity; magnesium ion binding; zinc ion binding