Recombinant Human ALOX15B Protein, His-tagged

• Cat.No.: ALOX15B-054H
• Product Overview: Active human recombinant C-terminal His-tagged human ALOX15B protein was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.
• Molecular Mass: 76 kDa
• Purity: ≥85% estimated by SDS-PAGE
• Unit Definition: One unit is defined as the amount of enzyme required to produce 1 nmol of 15-HpETE per min at 30 centigrade in 50mM Tris-HCl, pH7.2, with 0.003% Polysorbate 20, and 250 μM arachidonic acid.
• Stability: ≥ 1 year
• Storage: At -80 centigrade.

Gene Information

• Gene Name: ALOX15B arachidonate 15-lipoxygenase type B [ Homo sapiens (human) ]
• Official Symbol: ALOX15B
• Synonyms: ALOX15B; arachidonate 15-lipoxygenase type B; 15-LOX-2; polyunsaturated fatty acid lipoxygenase ALOX15B; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenase 2; arachidonate 15-lipoxygenase type II; arachidonate 15-lipoxygenase, second type; arachidonate omega(6) lipoxygenase; linoleate 13-lipoxygenase 15-LOb; EC 1.13.11.33
• Gene ID: 247
• mRNA Refseq: NM_001141
• Protein Refseq: NP_001132
• MIM: 603697
• UniProt ID: O15296