ALOX15B
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Official Full Name
arachidonate 15-lipoxygenase, type B -
Overview
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
ALOX15B;arachidonate 15-lipoxygenase, type B;arachidonate 15 lipoxygenase, second type;arachidonate 15-lipoxygenase B;15 LOX 2;15-LOX-B;15S-lipoxygenase;arachidonate 15-lipoxygenase 2;arachidonate omega(6) lipoxygenase;arachidonate 15-lipoxygenas
Recombinant Proteins
- Human
- Rat
- Insect Cells
- Wheat Germ
- E.coli
- Mammalian Cells
- In Vitro Cell Free System
- HEK293
- Fc
- His
- GST
- T7
- Non
- Avi
Involved Pathway
ALOX15B involved in several pathways and played different roles in them. We selected most pathways ALOX15B participated on our site, such as Arachidonic acid metabolism,Metabolic pathways,Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALOX15B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | PLA2G10,CYP2C37,PTGES3A,PTGS2A,CYP2V1,CYP2J6,CYP2C9,GGT1A,CYP2AD6,GPX3 |
| Serotonergic synapse | SLC6A4,PTGS2,Casp3,MAPK3,TPH1,GNG7,HTR1B,GNG2,CYP2C38,HTR1E |
| Metabolic pathways | INPP5A,POLR2L,CECR1A,GLULB,ATP5A1,CYP26B1,DGKE,HPD,MAOA,PNLIPRP3 |
Protein Function
ALOX15B has several biochemical functions, for example, arachidonate 15-lipoxygenase activity,arachidonate 8(S)-lipoxygenase activity,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALOX15B itself. We selected most functions ALOX15B had, and list some proteins which have the same functions with ALOX15B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| arachidonate 8(S)-lipoxygenase activity | ALOX8 |
| iron ion binding | CYP2P6,CYP27A1,CYP11B1,ALKBH8,TPH1B,CYGB1,CYP2F1,CYP4F18,TPH2,ALOX12E |
| linoleate 13S-lipoxygenase activity | ALOX12,ALOX8 |
| calcium ion binding | CAPN11,CABP5A,LTBP3,PCDH2G10,EPS15L1,SLC24A1,S100A14,DGKAA,AKR1C1,LTBP1 |
| arachidonate 15-lipoxygenase activity | ALOX15,ALOX8 |
| lipid binding | FFAR2,Fert2,FAM123A,APOL2,BAIAP2L2B,CYTH4,ACBD7,APOA4B.2,RBP7B,SEC14L4 |
Interacting Protein
ALOX15B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALOX15B here. Most of them are supplied by our site. Hope this information will be useful for your research of ALOX15B.
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