Recombinant Human AEN Protein (117-325 aa), His-SUMO-tagged

• Cat.No.: AEN-1066H
• Product Overview: Recombinant Human AEN Protein (117-325 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Cell Biology. Protein Description: Partial.

Specification

• Species: Human
• Source: E.coli
• Tag: His&SUMO
• Protein Length: 117-325 aa
• Description: Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancent of apoptosis.
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 40.1 kDa
• AA Sequence: MVGTGPRGRVSELARCSIVSYHGNVLYDKYIRPEMPIADYRTRWSGITRQHMRKAVPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPRSQTRDTTYVPNFLSEPGLHTRARVSLKDLALQLLHKKIQVGQHGHSSVEDATTAMELYRLVEVQWEQQEARSLWTCPEDREPDSSTDMEQYMEDQYWPDDLAHGSRGGAREAQDRRN
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: AEN apoptosis enhancing nuclease [ Homo sapiens ]
• Official Symbol: AEN
• Synonyms: AEN; FLJ12484; FLJ12562; ISG20L1; pp12744
• Gene ID: 64782
• mRNA Refseq: NM_022767
• Protein Refseq: NP_073604
• MIM: 610177
• UniProt ID: Q8WTP8