Recombinant Human ADSL, GST-tagged
| Cat.No. : | ADSL-9449H |
| Product Overview : | Recombinant Human ADSL protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
| Unit | |
| Price | |
| Qty |
- Specification
- Gene Information
- Related Products
- Download
| Description : | Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene. |
| Source : | E.coli |
| Species : | Human |
| Tag : | GST |
| Protein length : | 1-354a.a. |
| Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
| Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
| Gene Name | ADSL adenylosuccinate lyase [ Homo sapiens ] |
| Official Symbol | ADSL |
| Synonyms | ADSL; adenylosuccinate lyase; adenylosuccinase; ASL; AMPS; ASASE; |
| Gene ID | 158 |
| mRNA Refseq | NM_000026 |
| Protein Refseq | NP_000017 |
| MIM | 608222 |
| UniProt ID | P30566 |
| Chromosome Location | 22q13.1 |
| Pathway | Alanine, aspartate and glutamate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, conserved biosystem; Inosine monophosphate biosynthesis, PRPP + glutamine => IMP, organism-specific biosystem; Inosine monophosphate biosynthesis, PRPP + glutamine => IMP, conserved biosystem; Metabolic pathways, organism-specific biosystem; |
| Function | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; NOT N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; N6-(1,2- |
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Ask a Question for All ADSL Products
Required fields are marked with *
My Review for All ADSL Products
Required fields are marked with *
0
Inquiry Basket
