Recombinant Human ADM
Cat.No. : | ADM-27104TH |
Product Overview : | Recombinant fragment of Human Adrenomedullin with N terminal proprietary tag, 37.73kDa. |
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Species : | Human |
Source : | Wheat Germ |
Tag : | Non |
Protein Length : | 110 amino acids |
Description : | Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. |
Molecular Weight : | 37.730kDa inclusive of tags |
Tissue specificity : | Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | ARLDVASEFRKKWNKWALSRGKRELRMSSSYPTGLADVKA GPAQTLIRPQDMKGASRSPEDSSPDAARIRVKRYRQSMNN FQGLRSFGCRFGTCTVQKLAHQIYQFTDKD |
Sequence Similarities : | Belongs to the adrenomedullin family. |
Gene Name | ADM adrenomedullin [ Homo sapiens ] |
Official Symbol | ADM |
Synonyms | ADM; adrenomedullin; AM; |
Gene ID | 133 |
mRNA Refseq | NM_001124 |
Protein Refseq | NP_001115 |
MIM | 103275 |
Uniprot ID | P35318 |
Chromosome Location | 11 |
Pathway | Calcitonin-like ligand receptors, organism-specific biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; |
Function | adrenomedullin receptor binding; hormone activity; receptor binding; |
◆ Recombinant Proteins | ||
ADM-1365M | Recombinant Mouse ADM Protein | +Inquiry |
Adm-235R | Recombinant Rat Adm Protein, His-tagged | +Inquiry |
ADM-351M | Recombinant Mouse ADM Protein, His (Fc)-Avi-tagged | +Inquiry |
ADM-362H | Recombinant Human ADM Protein, GST-tagged | +Inquiry |
Adm-545M | Recombinant Mouse Adm Protein, MYC/DDK-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
ADM-1530HCL | Recombinant Human ADM cell lysate | +Inquiry |
Not For Human Consumption!
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