Recombinant Human ACY1 Protein, DDK-tagged

• Cat.No.: ACY1-1152H
• Product Overview: Recombinant human ACY1 protein, fused to DDK tag at C-terminus, was expressed in Insect cell.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Flag
• Description: This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010].
• Form: 50 mM Tris.HCl, pH 8.0, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 45.7 kDa
• Purity: >50 ug/mL as determined by microplate BCA method
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: ACY1 aminoacylase 1 [ Homo sapiens ]
• Official Symbol: ACY1
• Synonyms: ACY-1; ACY1D; HEL-S-5
• Gene ID: 95
• mRNA Refseq: NM_000666
• Protein Refseq: NP_000657
• MIM: 104620
• UniProt ID: Q03154