Recombinant Human Activin A Receptor Type II-Like 1

• Cat.No.: ACVRL1-483H

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Non
• Description: Activin A receptor type II-like 1, also known as ACVRL1, is a human gene. ACVRL1 is a receptor in the TGF beta signaling pathway. It is also known as "activin receptor-like kinase 1", or "ALK1". This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 suggesting a critical role for ALK-1 in the control of blood vessel development or repair.
• Molecular Weight: The predicted molecular weight of Recombinant Human ALK-1 is Mr 37.3 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 50-55 kDa.
• State Of Matter: Lyophilized.
• Purity: > 90% by SDS Page and analyzed by silver stain.
• Endotoxin: < 1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: ACVRL1 activin A receptor type II-like 1 [ Homo sapiens ]
• Synonyms: ACVRL1; activin A receptor type II-like 1; HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1; activin A receptor type II-like 1; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 1; serine/threonine-protein kinase receptor R3; EC 2.7.11.30
• Gene ID: 94
• mRNA Refseq: NM_000020
• Protein Refseq: NP_000011
• UniProt ID: P37023
• Chromosome Location: 12q11-q14
• MIM: 601284
• Pathway: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
• Function: ATP binding; SMAD binding; activin receptor activity, type I; magnesium ion binding; nucleotide binding; receptor activity; transferase activity; transforming growth factor beta binding