Acvrl1
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Official Full Name
activin A receptor type II-like 1 -
Overview
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008] -
Synonyms
ACVRL1;activin A receptor type II-like 1;HHT;ALK1;HHT2;ORW2;SKR3;ALK-1;TSR-I;ACVRLK1;serine/threonine-protein kinase receptor R3;TGF-B superfamily receptor type I;activin A receptor, type II-like kinase 1
Recombinant Proteins
- Human
- Mouse
- Rat
- Cynomolgus
- Canine
- Zebrafish
- HEK293
- Human Cells
- Sf9 Cells
- Wheat Germ
- Insect Cells
- Mammalian Cells
- E.coli
- His
- Fc&His
- Fc
- GST
- Non
- DDK&Myc
- Flag
- Avi&Fc&His
Involved Pathway
Acvrl1 involved in several pathways and played different roles in them. We selected most pathways Acvrl1 participated on our site, such as ALK1 pathway,ALK1 signaling events,Id Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Acvrl1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Id Signaling Pathway | MYF6,TCF3B,ELK3,MSC,PAX2,MYOD1,IFI16,MYOG,TCF12,KDR |
| ALK1 pathway | FKBP1A |
| TGF-beta Receptor Signaling Pathway | MEF2AA,GIPC1,ENG,NFYBB,SNIP1,CITED1,HOXD9A,CTCF,COPS5,TGFBR3 |
| ALK1 signaling events | GDF2,CSNK2B,FKBP1A |
Protein Function
Acvrl1 has several biochemical functions, for example, ATP binding,SMAD binding,activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Acvrl1 itself. We selected most functions Acvrl1 had, and list some proteins which have the same functions with Acvrl1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| activin binding | FKBP1A,TGFBR3,FSTL3,FST,SMAD7,ENG,ACVR1,ACVR2B,SMURF1 |
| transforming growth factor beta-activated receptor activity | LTBP1,TGFBR3,TGFBR2,ENG,TGFBR1,BMPR2B,BMPR2A |
| ATP binding | HSPD1,HSPA4L,CERK,CDK14,YSK4,MAGI1,ZRANB3,PFAS,TRP53,ATP11C |
| metal ion binding | Adcy4,ZIC2,STAMBPL1,BMPR1BB,NUBPL,MT4,PDE7A,SEMG2,MOB2,LIMCH1A |
| contributes_to activin receptor activity, type I | ACVR1 |
| activin receptor activity, type I | ACVR1B,ACVR1C |
| protein serine/threonine kinase activity | SRPK1B,SRPK3,CSNK1D,MYO3A,NEK9,RPS6KA2,TGFBR1A,NEK12,CHEK1,ACVR2AA |
| SMAD binding | PRDM16,TGFBR3,ACVR1B,BMP2,BMPR1A,SKOR1B,SKIB,TOB1,TGFBR2,USP15 |
| protein kinase binding | PIWIL1,DNM1,ADCY6,PTPN1,FBXW5,MEF2A,GRB7,RCC2,CEP152,PAX6 |
Interacting Protein
Acvrl1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Acvrl1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Acvrl1.
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