Recombinant Human Activin A
Cat.No. : | INHBA-2884H |
Product Overview : | Human Activin A produced in Insect cells is a 26 kDa disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues. |
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Species : | Human |
Source : | Insect Cells |
Tag : | Non |
Description : | Activin A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin. |
Form : | Lyophilized. |
Purity : | > 95% by SDS-PAGE and HPLC analyses. |
Endotoxin Level : | < 0.1 ng per μg of Activin A. |
Biological Activity : | The ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is < 2 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg. |
Reconstitution : | The human Activin A should be reconstituted in water to a concentration of 0.5 mg/ml. This solution can be stored at 4°C for 1 month or -20°C for future use. It is recommended that further dilutions be made in PBS containing 2 mg/ml albumin and stored at -20°C. |
Stability : | The lyophilized protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Human Activin A is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze-thaw cycles. |
Gene Name | INHBA inhibin, beta A [ Homo sapiens ] |
Synonyms | INHBA; inhibin, beta A; EDF; FRP; Inhibin, beta-1; OTTHUMP00000207260; FSH-releasing protein; erythroid differentiation factor; follicle-stimulating hormone-releasing protein; inhibin, beta A (activin A, activin AB alpha polypeptide); Activin beta-A chain; Erythroid differentiation protein; FSH-releasing protein |
Gene ID | 3624 |
mRNA Refseq | NM_002192 |
Protein Refseq | NP_002183 |
MIM | 147290 |
UniProt ID | P08476 |
Chromosome Location | 7p15-p13 |
Pathway | Cytokine-cytokine receptor interaction; TGF-beta signaling pathway |
Function | cytokine activity; follistatin binding; growth factor activity; hormone activity; identical protein binding; protein heterodimerization activity; signal transducer activity |
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INHBA-2884H | Recombinant Human Activin A | +Inquiry |
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◆ Cell & Tissue Lysates | ||
INHBA-2078MCL | Recombinant Mouse INHBA cell lysate | +Inquiry |
Not For Human Consumption!
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