Recombinant Human Activating Transcription Factor 2, GST-tagged

• Cat.No.: ATF2-1432H
• Product Overview: Recombinant human ATF2 (1-254) was expressed inE. colicells using a N-terminal GST tag. MW=55kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-254 a.a.
• Description: Activating transcription factor (ATF)-2, also designated CRE-BP1, is a member of the ATF/cyclic AMP-responsive element binding protein family of transcription factors. ATF2 has two unique characteristics: it mediates the adenovirus E1A-induced trans-activation and forms a heterodimer with c-Jun. ATF2 is a target of the JNK signal transduction pathway. ATF2 is phosphorylated by JNK on two closely spaced threonine residues within the NH2-terminal activation domain. The replacement of these phosphorylation sites with alanine inhibited the transcriptional activity of ATF2. Furthermore, p38 MAPK can also phosphorylate ATF2.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: ATF2 activating transcription factor 2 [ Homo sapiens ]
• Synonyms: ATF2; activating transcription factor 2; HB16; CREB2; TREB7; CRE-BP1; MGC111558; cAMP responsive element binding protein 2; clic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; cAMP response element-binding protein CRE-BP1; Cyclic AMP-responsive element-binding protein 2; CREB-2
• Gene ID: 1386
• mRNA Refseq: NM_001880
• Protein Refseq: NP_001871
• UniProt ID: P15336
• Chromosome Location: 2q32
• MIM: 123811
• Pathway: MAPK signaling pathway; Signaling in Immune system
• Function: RNA polymerase II transcription factor activity; metal ion binding; protein dimerization activity; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity; zinc ion binding