Recombinant Human Activating Transcription Factor 1, GST-tagged

• Cat.No.: ATF1-1431H
• Product Overview: Recombinant human full-length ATF1 was expressed inSf9 insect cellsusing a N-terminal GST tag. MW=63kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: ATF1 is a class of transcription factor that stimulates gene expression of several cell growth-related genes through protein kinase A-related cAMP response elements. ATF1 can physically associate with BRCA1 in vitro, in yeast, and in human cells and BRCA1 is implicated in the transcriptional activation of ATF1 target genes, some of which are involved in the transcriptional response to DNA damage. Mitogen- and stress-activated protein kinase 1 (MSK1) and MSK2 play a role in the stress-induced phosphorylation of ATF1 in primary embryonic fibroblasts. However, mitogen-induced phosphorylation of ATF1 is greatly reduced.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: ATF1 activating transcription factor 1 [ Homo sapiens ]
• Synonyms: ATF1; activating transcription factor 1; TREB36; EWS-ATF1; FUS/ATF-1; Cyclic AMP-dependent transcription factor ATF-1; cAMP-dependent transcription factor ATF-1; Activating transcription factor 1; Protein TREB36
• Gene ID: 466
• mRNA Refseq: NM_005171
• Protein Refseq: NP_005162
• UniProt ID: AAB25878
• Chromosome Location: 12q13
• MIM: 123803
• Pathway: Signalling by NGF
• Function: protein dimerization activity; sequence-specific DNA binding; transcription factor activity