Recombinant Human acid phosphatase 2, lysosomal Protein, His tagged

• Cat.No.: ACP2-216H
• Product Overview: Recombinant human ACP2 protein (P11117-1) (Arg 31-Glu 380) with a His tag at the C-terminus was expressed in HEK293.

Specification

• Description: The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism.
• Source: HEK293
• Species: Human
• Tag: C-His
• Protein length: 31-380aa
• Molecular Mass: 41.9 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: ACP2 acid phosphatase 2, lysosomal [ Homo sapiens (human) ]
• Official Symbol: ACP2
• Synonyms: ACP2; acid phosphatase 2, lysosomal; lysosomal acid phosphatase; LAP
• Gene ID: 53
• mRNA Refseq: NM_001131064
• Protein Refseq: NP_001124536
• MIM: 171650
• UniProt ID: P11117