Recombinant Human ACD protein, His & T7-tagged

• Cat.No.: ACD-1657H
• Product Overview: Recombinant Human ACD aa. (Glu244~Pro432 (Accession # Q96AP0)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Species: Human
• Source: E.coli
• Tag: His&T7
• ProteinLength: Glu244~Pro432
• Description: This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 23.0kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >90%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
• Reconstitution: Reconstitute in sterile ddH2O.
• Isoelectric Point: 4.6

Gene Information

• Gene Name: ACD ACD, shelterin complex subunit and telomerase recruitment factor [ Homo sapiens (human) ]
• Official Symbol: ACD
• Synonyms: ACD; ACD, shelterin complex subunit and telomerase recruitment factor; PIP1; PTOP; TPP1; TINT1; adrenocortical dysplasia protein homolog; POT1 and TIN2-interacting protein; TIN2 interacting protein 1; adrenocortical dysplasia homolog
• Gene ID: 65057
• mRNA Refseq: NM_001082486.1
• Protein Refseq: NP_001075955.1
• UniProt ID: Q96AP0