ACD

  • Official Full Name

    adrenocortical dysplasia homolog (mouse)

  • Overview

    This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.

  • Synonyms

    ACD;adrenocortical dysplasia homolog (mouse);adrenocortical dysplasia protein homolog;Pip1;POT1 and TIN2 organizing protein;Ptop;TIN2 interacting protein 1;Tint1;Tpp1;POT1 and TIN2-interacting protein

Recombinant Proteins

  • Human
  • Rat
  • Zebrafish
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • His&Fc&Avi
  • His&T7
Cat.# Product name Source (Host) Species Tag Protein Length Price
ACD-3725H Recombinant Human ACD protein, His-tagged E.coli Human His 1-351 aa
ACD-154H Recombinant Human ACD Protein, GST-Tagged Wheat Germ Human GST
ACD-448R Recombinant Rat ACD Protein Mammalian Cell Rat His
ACD-7144Z Recombinant Zebrafish ACD Mammalian Cell Zebrafish His
ACD-9096HCL Recombinant Human ACD 293 Cell Lysate HEK293 Human Non
ACD-9097HCL Recombinant Human ACD 293 Cell Lysate HEK293 Human Non
ACD-0512H Recombinant Human ACD Protein (Glu217-Pro405), N-His-tagged E.coli Human His Glu217-Pro405
ACD-103R Recombinant Rat ACD Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
ACD-103R-B Recombinant Rat ACD Protein Pre-coupled Magnetic Beads HEK293 Rat
ACD-1657H Recombinant Human ACD protein, His & T7-tagged E.coli Human His&T7 Glu244~Pro432
Acd-481M Recombinant Mouse Acd Protein, His-tagged E.coli Mouse His Glu21~Glu175
Acd-482R Recombinant Rat Acd Protein, His-tagged E.coli Rat His Asn147~Glu342
ACD-776HF Recombinant Full Length Human ACD Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 544 amino acids

    Involved Pathway

    ACD involved in several pathways and played different roles in them. We selected most pathways ACD participated on our site, such as Cell Cycle,Cellular Senescence,Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Packaging Of Telomere Ends TERF2,TINF2,POT1,POT1A,TERF1
    Meiotic synapsis TERF2,POT1,SYCP1,TINF2,STAG1,SUN1,SYCP2,STAG2,SUN2,SYCE2
    Cellular responses to stress HMGA1B,RBBP4,CDKN2A,CBX8B,RB1CC1,HDAC6,GABARAP,KIAA1967,HIST1H1E,PRDX2
    Cell cycle RBL2,PANE1,PLK4,SPDL1,SKP2,THRSP,NCAPD2,SGOL2,SGOL1,GMNN
    Chromosome Maintenance POT1A,TINF2,WRAP53,CENPK,OIP5,TERF1,RUVBL2,CENPW,MIS18A,TERF2
    Cellular Senescence CEBPB,MINK1,ERF,HIST1H1C,BMI1B,KDM6B,LMNB1,RBB4L,SUZ12A,TERF2IP
    DNA Damage/Telomere Stress Induced Senescence HMGA1B,TERF2,TERF1,POT1,CABIN1,UBN1,HIST1H1E,ASF1A,HTATIP,HMGA1
    Meiosis TERF1,DMC1,TERF2,TERF2IP,SYCP2,STAG1,MND1,SYCE1,SYNE1,TINF2

    Protein Function

    ACD has several biochemical functions, for example, DNA binding,DNA polymerase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACD itself. We selected most functions ACD had, and list some proteins which have the same functions with ACD. You can find most of the proteins on our site.

    Function Related Protein
    protein binding SAV1,CDC37L1,DUSP26,CARD9,ANKRD45,TUT1,GLYAT,ARFGAP3,PFKFB1,STRADB
    DNA polymerase binding RAD51,FANCI,LONP1,PCNA,FANCD2,SMARCA4,HMGB1,CDK2AP1
    DNA binding ZFP668,POLR1E,DMRT3,TCF15,ZNF574,ZNF530,SRFB,ELK4,PARPBP,DEK

    Interacting Protein

    ACD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACD here. Most of them are supplied by our site. Hope this information will be useful for your research of ACD.

    POT1;TINF2;TINF2

    Resources

    References

    • Yang, JS; Kang, SS; et al. Evaluation of Anticoagulants for Serologic Assays of Cholera Vaccination. CLINICAL AND VACCINE IMMUNOLOGY 21:854-858(2014).
    • Poli, M; Asperti, M; et al. Hepcidin antagonists for potential treatments of disorders with hepcidin excess. FRONTIERS IN PHARMACOLOGY 5:-(2014).

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