Recombinant Human ABL1, SH3 Domain, GST-tagged

• Cat.No.: ABL1-162H

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Description: N-terminal GST tagged Abl SH3 domain. Abl SH3 domain is the SH3 domain of Abl tyrosine kinase. SH3 domains are known to bind proline rich peptides. The Abl SH3 domain has been expressed as a fusion protein with GST allowing expression in E. coli and purification by affinity chromatography. The native GST-Abl-SH3 is the ideal tool for in vitro/in vivo investigations of the behaviour of cellular prions. It may be used for protein-protein interaction studies as well as for in vitro/in vivo conversion studies. The GST-Tag facilitates the protein's application in typical GST pull-down assays.
• Form: Lyophilized.
• Purity: ≥90% by SDS-PAGE.
• Usage: For in vitro use only.
• Storage: Quality guaranteed for 12 months store at -20°C. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: ABL1 c-abl oncogene 1, receptor tyrosine kinase [ Homo sapiens ]
• Synonyms: ABL1; c-abl oncogene 1, receptor tyrosine kinase; ABL; JTK7; p150; c-ABL; v-abl; bcr/abl; bcr/c-abl oncogene protein; proto-oncogene tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1; EC 2.7.10.2;Abelson murine leukemia viral oncogene homolog 1; OTTHUMP00000022375; OTTHUMP00000022376
• Gene ID: 25
• mRNA Refseq: NM_005157
• Protein Refseq: NP_005148
• MIM: 189980
• UniProt ID: P00519
• Chromosome Location: 9q34.1
• Pathway: Axon guidance; Cell cycle; Chronic myeloid leukemia; ErbB signaling pathway; Neurotrophin signaling pathway; Pathogenic Escherichia coli infection; Pathways in cancer
• Function: ATP binding; DNA binding; magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein C-terminus binding; transferase activity