ABL1
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Official Full Name
c-abl oncogene 1, non-receptor tyrosine kinase -
Overview
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008] -
Synonyms
ABL1;c-abl oncogene 1, non-receptor tyrosine kinase;ABL;JTK7;p150;c-ABL;v-abl;c-ABL1;bcr/abl;tyrosine-protein kinase ABL1;proto-oncogene c-Abl;bcr/c-abl oncogene protein;Abelson tyrosine-protein kinase 1;c-abl oncogene 1, receptor tyrosine kinase;proto-oncogene tyrosine-protein kinase ABL1;v-abl Abelson murine leukemia viral oncogene homolog 1
Recombinant Proteins
- Human
- Mouse
- Insect Cells
- E.coli
- Sf9 Cells
- Wheat Germ
- Mammalian Cells
- HEK293
- Human Plasma
- Sf21 Cells
- GST
- His
- GST&His
- Flag
- Non
- Flag&His
- Avi&Fc&His
Involved Pathway
ABL1 involved in several pathways and played different roles in them. We selected most pathways ABL1 participated on our site, such as ErbB signaling pathway,Ras signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | EPHA8,SEMA5B,EGF,AP2A1,EFNA3,CHL1,KIF4A,PAQR3B,ROCK2,EZRA |
| Ras signaling pathway | RAB5C,PLA2G2D,PDGFRB,NGF,PAK6,SOS1,PRKACG,FGF22,IGF1,ANGPT1 |
| Cell Cycle | DYRK1A,PTTG1,AKAP9,CLASP1A,CCND2A,TUBGCP4,WAPAL,ZBTB17,CNEP1R1,ORC6L |
| Shigellosis | MAPK10,ACTB,MAPK3,RHOG,PFN4,ROCK2,MAPK12,ELMO2,WASF1,NFKBIB |
| Pathways in cancer | PTEN,MAPK8,Shh,FOXO1,MMP1A,TRAF3,PIK3CD,ITGA2,RAC1,PTCH2 |
| MicroRNAs in cancer | ZEB1,EZR,MAPK7,PTEN,CDCA5,TP53,TIMP3,KIF23,ROCK1,PIM1 |
| ErbB signaling pathway | CAMK2A,EREG,CAMK2D1,MAPK8,PAK6,PLCG2,CDKN1BB,NCK1,MAP2K4B,PAK7 |
| Viral myocarditis | ITGB2,CYCS,ICAM1,HLA-DMB,HLA-DRB5,CD40LG,LAMA2,CASP8,HLA-DPB1,CD80 |
| Chronic myeloid leukemia | TRP53,MECOM,PIK3CA,IKBKB,CBLC,TP53,PIK3CB,MAPK3,AKT2,MAPK1 |
Protein Function
ABL1 has several biochemical functions, for example, ATP binding,DNA binding,SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABL1 itself. We selected most functions ABL1 had, and list some proteins which have the same functions with ABL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| non-membrane spanning protein tyrosine kinase activity | PKDCC,FYNB,LYN,JAK2B,TYK2,Fert2,CSK,ZNF143B,CLK1,STYK1 |
| protein C-terminus binding | BLOC1S2A,PRDX3,TRP53,TERF2,PHB,SLC4A1,VPS4A,LIG4,BCAM,MAPRE1 |
| ATP binding | DNAJA3A,SIK3,DQX1,STK26,SMCHD1,RAD51C,KLHL8,ACSL1,PRKAA2,PSMC1A |
| protein binding | Tnfrsf22,KCNN4,NOA1,DDAH2,TMEM119,SMARCD1,TMEM59,SSX3,CC10,POLR3F |
| SH3 domain binding | PAK3,MYPN,KHDRBS2,NCKIPSD,RAD9A,KHDRBS1,PLSCR1,ENKUR,FMN1,SH3BGRL2 |
| manganese ion binding | MPPE1,PPM1BB,GLUL,ABL2,PPM1M,LARGE,PPM1A,PPM1N,GALNT1,B4GALT7 |
| syntaxin binding | VPS52,STXBP5A,SYT7,SYT13,VPS18,SYT1A,SYT5A,SYT9B,PTPN2,STXBP3A |
| proline-rich region binding | ITSN1,GAREM,PFN1,GHR,WBP4,CYLD,RABAC1,ABI2,APBB1,PRPF40A |
| receptor binding | CHRNA10,FGF13A,GFRA1,CD2,PVRL1,FGF11A,RND1,P2RX4,SSFA2,FGF10A |
Interacting Protein
ABL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABL1.
ABI1;MSH5
Resources
Research Area
Cancer Drug TargetsReceptor Tyrosine Kinases (RTKs) in the Akt Pathway
Wnt Intracellular Signaling
Kinases Localized to Focal Adhesions
Tumor Antigens
Oncoprotein-Signal Transducers
Related Services
Related Products
References
- Murray, JC; Aldeghaither, D; et al. c-Abl Modulates Tumor Cell Sensitivity to Antibody-Dependent Cellular Cytotoxicity. CANCER IMMUNOLOGY RESEARCH 2:1186-1198(2014).
- Krause, DS; Lazarides, K; et al. Selectins and their ligands are required for homing and engraftment of BCR-ABL1(+) leukemic stem cells in the bone marrow niche. BLOOD 123:1361-1371(2014).
