Recombinant Human ABCC2 Protein (M1-F1545), eGFP, Strep II, 10×His tagged

• Cat.No.: ABCC2-0107H
• Product Overview: Recombinant Human ABCC2(M1-F1545 end)-3C-eGFP-Strep II-10His Protein was expressed in Mammalian cell.

Specification

• Description: ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification. Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Transports sulfated bile salt such as taurolithocholate sulfate. Transport various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors. Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine.
• Source: Mammalian cell
• Species: Human
• Tag: His&StrepII&EGFP
• Form: Liquid
• Protein length: M1-F1545
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 80%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: 50mM Tris-HCl (pH 7.5), 150mM KCl, 2mM DTT, 2mM MgCl2, 0.005% GDN
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 [ Homo sapiens (human) ]
• Official Symbol: ABCC2
• Synonyms: ABCC2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; canalicular multispecific organic anion transporter 1, CMOAT; canalicular multispecific organic anion transporter 1; cMRP; DJS; MRP2; canalicular multidrug resistance protein; multidrug resistance-associated protein 2; ATP-binding cassette sub-family C member 2; ABC30; CMOAT
• Gene ID: 1244
• mRNA Refseq: NM_000392
• Protein Refseq: NP_000383
• MIM: 601107
• UniProt ID: Q92887