ABCC2
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Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -
Overview
Multi-drug resistance protein 2 (MRP2), also known as cMRP, cMOAT, and ABCC2, is an ATP binding cassette (ABC) transporter and part of the multi-drug resistance (MRP) family. The MRP proteins are membrane proteins that function as organic anion pumps invo -
Synonyms
ABCC2;ATP-binding cassette, sub-family C (CFTR/MRP), member 2;canalicular multispecific organic anion transporter 1 , CMOAT;canalicular multispecific organic anion transporter 1;cMRP;DJS;MRP2;canalicular multidrug resistance protein;multidrug resistance-associated protein 2;ATP-binding cassette sub-family C member 2;ABC30;CMOAT
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Rat
- Cynomolgus
- Arabidopsis thaliana
- E.coli
- Wheat Germ
- Mammalian Cells
- Sf9 Cells
- HEK293
- GST
- His
- Non
- EGFP
- Strep II
- Avi
- Fc
Involved Pathway
ABCC2 involved in several pathways and played different roles in them. We selected most pathways ABCC2 participated on our site, such as ABC transporters,ABC-family proteins mediated transport,Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nuclear receptors in lipid metabolism and toxicity | RARGB,CYP27B1,CYP26A1,VDRB,CYP24A1,NR1I3,RARGA,NR1I2,RARG |
| ABC transporters | ABCA7,ABCC6,ABCC8,ABCB6A,SUR2A,ABCD3,ABCC1,ABCB6,Abcb1b,ABCC12 |
| Drug Induction of Bile Acid Pathway | SLC51B,CYP7A1,SLCO1B1,NR1I3,NR1I2 |
| Bile secretion | RXRA,ATP1B3,ATP1B2,PRKACB,PRKACA,ABCB1A,SCTR,EPHX1,Slc4a2,SLCO1B1 |
| ABC-family proteins mediated transport | ABCA7,ABCC9,ABCB8,KCNJ11,ABCA8,ABCG4B,EIF2S3,EIF2S1,ABCD3B,ABCA4A |
| Transmembrane transport of small molecules | SLC9A5,SLC5A4,SLC9A8,TRPC5,ASPH,SLC4A1A,SLC39A6,ABCB8,ANO5,TRPC5A |
Protein Function
ABCC2 has several biochemical functions, for example, ATP binding,ATPase activity, coupled to transmembrane movement of substances,organic anion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC2 itself. We selected most functions ABCC2 had, and list some proteins which have the same functions with ABCC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase activity, coupled to transmembrane movement of substances | ABCB1A,ABCG2A,ABCA6,ABCB3L1,ABCC1,ABCG2,ABCD4,ABCC5,ABCA1,ABCD1 |
| organic anion transmembrane transporter activity | ABCC3,SLCO1B2,SLCO1D1,SLC22A7B.1,MFSD10,SLC22A23,SLCO4C1,SLCO1A4,SLC17A3,SLC22A7A |
| ATP binding | BRAF,EIF2AK2,DDX54,NUAK2,HELLS,MYHZ1.1,GLULA,GPHN,KDRL,ACACB |
| protein binding | PPP2R2B,PATL1,GGACT,PRKRIP1,KLC4,PDE6D,THRAP3,TRIP12,TRPV6,SETX |
| protein domain specific binding | FOXH1,CHMP2A,FOXA1,MPP5,ACSL3,ARFIP2B,DBNL,BHLHE40,YWHAG1,ODF1 |
Interacting Protein
ABCC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC2.
NFKB1;AZIN1;MCPH1;SHANK3;UBQLN1
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References
- Reiner, Z; et al. Resistance and intolerance to statins. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 24:1057-1066(2014).
- Haslam, IS; Simmons, NL; et al. Expression of the ABC transport proteins MDR1 (ABCB1) and BCRP (ABCG2) in bovine rumen. JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY 184:673-681(2014).
