Recombinant HCV Nucleocapsid Protein, Biotin-labeled & beta-galactosidase conjugated

• Cat.No.: Nucleocapsid-749H
• Product Overview: The protein contains the HCV core nucleocapsid immunodominant regions, amino acids 2-192, with a molecular weight of 22 kDa and is biotin conjugated.The protein is fused to beta-galactosidase (114 kDa) at the N-terminus. Hepatitis C Virus core proteins are purified by proprietary chromatographic techniques.

Specification

• Species: HCV
• Source: E.coli
• Tag: Non
• ProteinLength: 2-192 a.a.
• Description: The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum (ER) Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However, the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways In addition, HCV core antigen is a recently developed marker of hepatitis C infection. It is remarkably efficient at establishing persistent infection, suggesting that it has evolved one or more strategies aimed at evading the host immune response. T cell responses, including interferon-gamma production, are severely suppressed in chronic HCV patients. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR.
• Form: 20 mM Tris-HCl pH 8.0 and 8 M urea
• Molecular Mass: 136 kDa
• Purity: > 95 % (SDS-PAGE)
• Applications: ELISA; Western Blot
• Storage: Store at -20 centigrade, avoid freeze/thaw cycles.

Gene Information

• Official Symbol: Nucleocapsid
• Synonyms: Nucleocapsid