Recombinant Guinea Pig Histamine Receptor H 2

• Cat.No.: Hrh2-1043G

Specification

• Species: Guinea Pig
• Source: Sf9 Cells
• Tag: Non
• Description: The histamine H2-receptor (H₂R) belongs to the superfamily of seven transmembrane domain (7TM), G-protein-coupled receptors (GPCRs). The endogenous agonist for the H₂R is histamine which is both neurotransmitter and autacoid.The H₂Rcouples to Gs-proteinsto mediate adenylate cyclase (AC) activation. In some systems, the H₂R also couples to Gq-proteins and phospholipase C. Among the many responses mediated by the H₂R are gastric acid secretion, smooth muscle relaxation, positive ionotropic and chronotropic effects on heart muscle, and inhibition of leukocyte function. The guinea pig H2R (gp H₂R) was prepared from Sf9 cells infected with gp H₂R -encoding baculovirus. In this system, gp H2R couples to the Gs-like G-proteins of the insect cells to mediate AC activation. gp H2R contains a N-terminal FLAG-tag and a Cterminal hexahistidine (His6)-tag for immunological detection, to allow purification, and to provide additional protection against proteolysis.
• Form: Membrane suspension. Supplied in 75 mM Tris-HCl, pH 7.4, 12.5 mM MgCl₂and 1 mM EDTA.
• Usage: For in vitro use only.
• Storage: Quality guaranteed for 12 months. Store at -80°C. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: Hrh2 histamine receptor H 1 [ Cavia porcellus ]
• Synonyms: Hrh2; histamine receptor H 2; histamine H2 receptor
• Gene ID: 100135540
• UniProt ID: P47747