Recombinant Full Length Human RNASEH2A Protein, MYC/DDK-tagged

• Cat.No.: RNASEH2A-1257H
• Product Overview: Recombinant human RNASEH2A protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Protein Length: 1-299 a.a.
• Description: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009].
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 33.2 kDa
• Purity: >50 ug/mL as determined by microplate BCA method
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: RNASEH2A ribonuclease H2, subunit A [ Homo sapiens ]
• Official Symbol: RNASEH2A
• Synonyms: AGS4; JUNB; RNASEHI; RNHIA; RNHL
• Gene ID: 10535
• mRNA Refseq: NM_006397
• Protein Refseq: NP_006388
• MIM: 606034
• UniProt ID: O75792