Recombinant Full Length Human RIPK1 Protein, N-His-tagged

• Cat.No.: RIPK1-14HFL
• Product Overview: Recombinant Full Length Human RIPK1 Protein, fused to His-tag at N-terminus, was expressed in E. coli.

Specification

• Description: This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.
• Molecular Mass: 75.8 kDa
• AA Sequence: A DNA sequence encoding human full-length RIPK1.
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Apoptosis, Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway
• Full Length: Full L.

Gene Information

• Gene Name: RIPK1 receptor interacting serine/threonine kinase 1 [ Homo sapiens (human) ]
• Official Symbol: RIPK1
• Synonyms: RIP; RIP1; AIEFL; IMD57; RIP-1
• Gene ID: 8737
• mRNA Refseq: NM_003804.6
• Protein Refseq: NP_003795.2
• MIM: 603453
• UniProt ID: Q13546